The pathophysiological event leading to neurosensory retinal detachment remains unknown. Most researchers believe that stasis, inflammation or a combination of the above factors leads to abnormal permeability of the inner chorio capillaries and eventful elevation of RPE and serous retinal detachment. Yet the presence of these pathologic mechanisms in the choroid still cannot replicate the constellation of findings in this disorder. In the acute form of the disease, many believe that there is a disruption in the continuity of the detached RPE, leading to focal leakage beneath an overlying neurosensory retinal detachment, the signature of the disorder. This form of mechanical alteration in the integrity of the RPE, referred to as a blow -out or micro rip, alters its normally impermeable stable leading to serous detachment of retina. In this sense, the retina seems to be affected secondarily; whereas inner choroidal changes represent the primary abnormality of the disorder, leading to current designation of the disease as CSCR. The primary exudative disturbance in the inner choroid, resulting in macular detachment is thought to be non-vasogenic that is not associated with proliferation of choroidal vessels. The initial avascular nature of CSCR distinguishes it from other forms of macular detachment associate with neovascularization of the choroid and eventual disciform scarring.
FFA CHANGES IN CENTRAL SEROUS CHORIO RETINOPATHY, Dr Rajeevan.P., Riswan Rasheed, INTERNATIONAL JOURNAL OF ADVANCED MEDICINE : Volume-4 | Issue-3 | May-2020