Biochemical Significance Of Ischemia Modified Albumin: A Novel Biochemical Marker Of Myocardial Ischemia In The Early Diagnosis Of Acute Coronary Syndrome

Abstract :

Introduction: The term acute coronary syndrome (ACS) is used for a series of myocardial ischemia, from angina to acute myocardial infarction. Due to associated with high mortality diagnosis of ACS is important before the irreparable damage occurs to myocardium. Aim: To evaluate the role of IMA as a novel cardiac marker of myocardial ischemia in early diagnosis of ACS within 6 hours onset of symptoms.Material & Methods:- Patients attending the emergency department (ED) within 6 hrs having ACS were selected. IMA was measured by Albumin cobalt binding test, Troponin I by I STAT cartridge and CK-MB by IFCC method. ROC cure was plotted to evaluate the diagnostic performance.Results:- There was significant increase in IMA levels in ACS group (124.87 19.48) than control (70.0626.31). At the cut off value 92.12 sensitivity was 99% which was higher than Troponin I (84%) and CK-MB (78%), but specificity of IMA (87%) was less than CK-MB (93%) and Troponin I (82%).Conclusion:- IMA appears to be a developing into a new marker for diagnosing of ACS in the initial hours after symptoms onset when the standard biomarkers may not be elevated.

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