Volume : VII, Issue : I, January - 2023
Introduction: The term acute coronary syndrome (ACS) is used for a series of myocardial ischemia, from angina to acute myocardial infarction. Due to associated with high mortality diagnosis of ACS is important before the irreparable damage occurs to myocardium. Aim: To evaluate the role of IMA as a novel cardiac marker of myocardial ischemia in early diagnosis of ACS within 6 hours onset of symptoms.Material & Methods:- Patients attending the emergency department (ED) within 6 hrs having ACS were selected. IMA was measured by Albumin cobalt binding test, Troponin I by I STAT cartridge and CK-MB by IFCC method. ROC cure was plotted to evaluate the diagnostic performance.Results:- There was significant increase in IMA levels in ACS group (124.87 19.48) than control (70.0626.31). At the cut off value 92.12 sensitivity was 99% which was higher than Troponin I (84%) and CK-MB (78%), but specificity of IMA (87%) was less than CK-MB (93%) and Troponin I (82%).Conclusion:- IMA appears to be a developing into a new marker for diagnosing of ACS in the initial hours after symptoms onset when the standard biomarkers may not be elevated.
BIOCHEMICAL SIGNIFICANCE OF ISCHEMIA MODIFIED ALBUMIN: A NOVEL BIOCHEMICAL MARKER OF MYOCARDIAL ISCHEMIA IN THE EARLY DIAGNOSIS OF ACUTE CORONARY SYNDROME, Durgesh Nandini Upadhyay, Dr. R.K.Vyas, Anita Rathore, Dr. Varun Yadav, Dr. Yogita Soni, Dr.Ved Prakash Agrawal, INTERNATIONAL JOURNAL OF ADVANCED MEDICINE : Volume-7 | Issue-1 | January-2023